� it the levels of iep, zn and changed after dialysis, due to the removal of molecules that were poorly linked mainly free peg at the outer part of the surface, lidocaine patch methotrexate allowing accessibility to the inner adjacent part of the shell water shell fig accessible layer to counter ions characterized by its thickness x lidocaine patch methotrexate and its dipolar charge density zn nm lnc presented the bestorganized and the accessible lidocaine patch methotrexate part of the shell, compared with other sizes of lnc, before and after dialysis lecithin was found to be present in the inner part of the polyelectrolyte layer and was found to play a role in the lidocaine patch methotrexate disorganization of the outer part lidocaine patch methotrexate dialyzing lnc formulated with lecithin led to stable and well structured nanocapsules, ready for an in vivo use as a drug delivery system evaluation of complement system activation generally, after intravenous administration, nanoparticles np are rapidly removed from the blood stream because they are recognized by cells of the mps such lidocaine patch methotrexate as kiipffer cells in the liver, or spleen and bonemarrow macrophages however, a brush of peg chains grafted on the surface is known to decrease the recognition of nanoparticles by the immune system after intravenous administration one has demonstrated that a strong correlation prevails between the complement activation and the stealthy qt donkey kick caffeine properties of lnc therefore, these properties were evaluated by measuring the degree of complement activation [ch technique and crossed immunoelectrophoresis c cleavage] and the level of macrophage uptake, in relation to the lidocaine patch methotrexate organization of peg chains, according to the electrokinetic properties of the lnc surface these experiments were performed on , and nm lnc before and after dialysis the ch technique is presented in fig nanoparticles are dispersed in human serum with sensitized erythrocytes after incubation, lysis is evaluated by a classical spectrophotometric method the measured absorbance is related to the consumption of complement proteins by particles the lidocaine patch methotrexate main conclusions are that whatever the in vitro test, all lnc were not recognized by the non specific components of the immune system it was probably due to the strong density of peg chains at their surface furthermore, dialysis maintains a sufficiently high density of peg and had no incidence on the complement consumption pharmacokinetic studies and biodistribution at first, the biodistribution of radiolabeled nanocapsules was studied by scintigraphy and � counting, after intravenous administration in rat whereby the mtcoxine was incorporated in the lipid core and i labelled the shell of the nanocapsules dynamic scintigraphic acquisition was carried out hrs after administration and � activity in blood and tissues was lidocaine patch methotrexate followed for more than lidocaine patch methotrexate hrs see fig an early lidocaine patch methotrexate halfdisappearance time of about � min was found for i and � min for mtc these ranges of residence times were interesting for specific �a st active wcd�s vcub nnnnil scrum cdds vr i ?